Highly potent anti-leishmanial derivatives of hederagenin, a triperpenoid from Sapindus saponaria L.
نویسندگان
چکیده
منابع مشابه
Spermicidal and anti-Trichomonas vaginalis activity of Brazilian Sapindus saponaria
BACKGROUND Sapindus saponaria is used traditionally for curing ulcers, external wounds and inflammations. The spermicidal and anti-Trichomonas activity of S. saponaria and its effect on Lactobacillus acidophilus were evaluated. METHODS Water-ethanol (WE) and butanolic (BE) extracts, as well as a purified sample of saponins (SP) from S. saponaria were tested for spermicidal and anti-Trichomona...
متن کاملAntifungal activity of the extracts and saponins from Sapindus saponaria L.
Extracts from the dried pericarp of Sapindus saponaria L. (Sapindaceae) fruits were investigated for their antifungal activity against clinical isolates of yeasts Candida albicans and C. non-albicans from vaginal secretions of women with Vulvovaginal Candidiasis. Four clinical isolates of C. albicans, a single clinical isolated of each of the species C. parapsilosis, C. glabrata, C. tropicalis,...
متن کاملCellular Structural Changes in Candida albicans Caused by the Hydroalcoholic Extract from Sapindus saponaria L.
Vulvovaginal candidiasis (VVC) is a disease caused by the abnormal growth of yeast-like fungi in the mucosa of the female genital tract. Candida albicans is the principal etiological agent involved in VVC, but reports have shown an increase in the prevalence of Candida non-C. albicans (CNCA) cases, which complicates VVC treatment because CNCA does not respond well to antifungal therapy. Our gro...
متن کاملDereplication of Glycosides from Sapindus saponaria using Liquid Chromatography-Mass Spectrometry
Frutos de Sapindus saponaria (Sapindaceae), uma planta amplamente distribuída nos trópicos, foram coletados a cada trinta dias, durante seis meses. Estudos usando cromatografia a líquido com detecção por UV e EM (CLAE/UV/ESI-EM) e fragmentações por EM/EM, mostraram que os principais glicosídeos presentes nesses frutos são saponinas (SAP) derivadas dos triterpenos hederagenina e ácido oleanólico...
متن کاملBiological Activity of Coumarin Derivatives as Anti-Leishmanial Agents
Cutaneous leishmaniasis affects nearly 0.7 to 1.3 million people annually. Treatment of this disease is difficult due to lack of appropriate medication and the growing problem of drug resistance. Natural compounds such as coumarins serve as complementary therapeutic agents in addition to the current treatment modalities. In this study, we have performed an in-silico screening of the coumarin de...
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ژورنال
عنوان ژورنال: European Journal of Medicinal Chemistry
سال: 2016
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2016.08.030